Vanadium intoxication inhibits sulfhydryl groups and glutathione in the rat brain.
نویسندگان
چکیده
منابع مشابه
Effect of acute and chronic lead exposure on the level of sulfhydryl groups in rat brain.
Lead is known to be a potent neurotoxic agent. The interactions of lead with proteins are considered to be at least one of the mechanisms due to which lead exerts its toxicity. In the present work we demonstrate that acute and chronic models of exposure to lead affected the level of total and protein-bound SH groups in homogenates and synaptosomes obtained from rat brains. The concentrations of...
متن کاملSulfhydryl Groups in Proteins
Egg albumin in the native, unaltered state, does not give tests characteristic of sulfhydryl groups. When, however, this protein is treated in any one of several ways, such as by heat (8, 9, 17), ultraviolet irradiation (lo), shaking (lo), or by solution in urea or other amides (7), free sulfhydryl groups make their appearance. The amount of free -SH groups appearing in egg albumin through the ...
متن کاملSulfhydryl Groups and the Structure of Hemoglobin
1. Addition of 2 moles of mersalyl, mercuric chloride, p-chloromercuribenzoate (PCMB), or methyl mercury hydroxide per mole of hemoglobin greatly reduces heme-heme interactions (n), yet these substances have quite different effects on the oxygen affinity (-log p(50)). Mersalyl and mercuric chloride at this concentration each increase the oxygen affinity, while PCMB and methyl mercury have littl...
متن کاملVanadium intoxication in albino rat based on haematobiochemistry and behaviouristic changes
Heavy metals are the source of substantial environmental and health problems. Vanadium pentaoxide (V2O5) is an environmental and industrial pollutant that affects body physiology via the food, drinking water and through the air. Toxicological study of V2O5, following acute (1day) and subacute (7, 14, 21 days) exposure, alter behaviour and serum biochemistry in Wistar rats in terms of significan...
متن کاملSulfhydryl Groups and the Interaction between the Hemes in Hemoglobin
1. Dialysis of a hemoglobin solution against slightly alkaline buffer (pH 8.68) causes a decrease in heme-heme interaction. The value of n in Hill's equation drops from 2.9 to 2.0, while the oxygen affinity increases slightly. Addition of glutathione largely reverses the effects of dialysis (n rises from 2.0 to 2.5 to 2.6). 2. Addition of the sulfhydryl reagent, p-chloromercuribenzoate (1.8 x 1...
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ژورنال
عنوان ژورنال: INDUSTRIAL HEALTH
سال: 1989
ISSN: 0019-8366,1880-8026
DOI: 10.2486/indhealth.27.23